Reishi can be used to assist immune drugs to fight cancer
- Categories:Ganoderma Encyclopedia
- Time of issue:2022-09-08 11:44
- Views:
Reishi can be used to assist immune drugs to fight cancer
- Categories:Ganoderma Encyclopedia
- Time of issue:2022-09-08 11:44
- Views:
The health benefits of "Ganoderma lucidum extract + sporoderm-broken spore powder" have been scientifically confirmed more than ten years ago. This mixed product can "protect the liver and reduce chemical liver damage (see part one of the trilogy)", "protect bone marrow and white blood cells and alleviate radiation damage(see part two of the trilogy)", as well as assist immune drugs to fight cancer and improve therapeutic effects (see part three of the trilogy).
In 2014, the research "Regulatory Effect of Ganoderma Lucidum Extract in Cancer Immunotherapy" published in Chinese Journal of General Practice by the Department of General Surgery of Zhejiang Provincial People's Hospital and the Department of Oncological Surgery of the Second Affiliated Hospital Zhejiang University School of Medicine confirmed that:
"The powerful immunoregulatory function of Ganoderma lucidum extract significantly improves the tumor-bearing body's tumor immunosuppression, significantly enhances the body's anti-tumor immune function and makes immunotherapy more effective."
According to the description in the report, the "Ganoderma lucidum extract" used in this study has a specific source of raw materials and production process. Each 100g of this product contains more than 10 g of Ganoderma lucidum polysaccharides and more than 8 g of Ganoderma lucidum total triterpenes. This product is also a product with "China health food approval number" approved by the national health food authority.
From the label on the product package, it can be seen that this Ganoderma lucidum extract preparation is actually mixed with a considerable proportion of sporoderm-broken Ganoderma lucidum spore powder. Therefore, the following "Regulatory Effect of Ganoderma Lucidum Extract in Cancer Immunotherapy" is actually produced by both Ganoderma lucidum extract and sporoderm-broken Ganoderma lucidum spore powder.
The researchers evaluated the regulatory effect of specific Ganoderma lucidum preparations in cancer immunotherapy through 90-day animal experiments.
The researchers first implanted liver cancer cells in the back of the mice. After the liver tumors grew, the mice were randomly divided into 6 groups with 10 mice in each group. Except for the control group, the other groups were simultaneously treated for 90 days:
The CpG-ODN used in the experiment is a synthetic immunotherapy drug, which can enhance the activity and killing ability of natural killer cells (NK) and improve the "non-specific immune function" of the immune system.
HSP70-PCs as tumor antigens are "tumor-derived heat shock protein (HSP)70 polypeptide complexes" purified from mouse liver cancer cells, which can enhance the ability of the immune system to recognize cancer cells and improve the "specific immune function" of the immune system.
Compared with the liver cancer mice without any treatment, the Ganoderma lucidum extract preparation supplemented with sporoderm-broken spore powder alone has a great effect:
● Tumor volume and tumor weight almost halved.
● The metastasis rate of cancer cells also dropped from 40% to 20%.
● Long-term survival rate also increased from “none at all” to 20%.
However, the experiment also found that whether the Ganoderma lucidum preparation is combined with tumor antigens or immunotherapy drugs, its effect on inhibiting tumor growth is better than that of any of the three alone. Especially when used in combination with immunotherapy drugs, the tumor disappears completely, no cancer metastasis occurs, and the long-term survival rate of the mice is increased to 100%.
Mechanism of Action: Boosts the immune system's ability to fight cancer
The researchers also detected anti-cancer-related immune factors in the peripheral blood of mice with liver cancer in each group. The results showed whether the factor was the cytokine IFN-γ(interferon), which helps inhibit tumor growth, or the chemokines CXCL-9 and CXCL-10, which inhibit cancer metastasis, the Ganoderma lucidum preparation can help improve the effects of the above-mentioned factors. Especially when it is used in combination with tumor antigens or immunotherapy drugs, the effect of improvement is better.
Cancer cells secrete a variety of immunosuppressive factors to facilitate cancer growth. However, the Ganoderma lucidum preparation used in the experiment, whether used alone or in combination with immunotherapy, can enhance the immune factors related to anti-cancer in liver cancer mice, indicating that this Ganoderma lucidum preparation with "Ganoderma lucidum extract + sporoderm-broken spore powder" as the connotation can break through the immunosuppression caused by tumors, and inject more vitality into the immune function required for tumor suppression.
It is worth mentioning that the IFN-γ that can be improved by the Ganoderma lucidum preparation in the experiment is also an indispensable weapon for the immune system to fight viruses!
Anti-cancer requires good immunity, and good immunity also requires good Ganoderma lucidum.
Fighting cancer is a long road. No matter what treatment a patient chooses, he or she ultimately needs the support of a well-functioning immune system to coexist with cancer for a long time.
In the face of the threat of cancer cells, what kind of food can help the immune system to function well continuously, assist modern tumor immunotherapy technology and protect against chemical liver damage and radiation damage by the way?
After reading the three research reports introduced in "Trilogy", readers should have no difficulty understanding that the preparation of "Ganoderma lucidum extract + sporoderm-broken spore powder" supported by specific production specifications, quality standards and scientific evidence is a choice worth considering.
[Source]
Linbo Zhu et al. The regulatory effect of Ganoderma lucidum extract in tumor immunotherapy. Chinese Journal of General Practice, 2014; 12(3): 341-343.
END
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★ The original text of this article was written in Chinese by Wu Tingyao and translated into English by Alfred Liu. If there is any discrepancy between the translation (English) and the original (Chinese), the original Chinese shall prevail. If readers have any questions, please contact the original author, Ms. Wu Tingyao.
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