Liver cancer is one of the most important cancers that threaten Chinese people. The treatment of liver cancer has also received widespread attention worldwide. Can Ganoderma lucidum be used to prevent and treat liver cancer?

According to the research report published in the "Modern Chinese Applied Pharmacy", Issue 9, 2011 by Professor Li Peng, Professor Wei Xiaoxia, and Professor Xu Jianhua of School of Pharmaceutics, Fujian Medical University, the Ganoderma lucidum extract with triterpenes as its main component has a significant inhibitory effect on liver cancer cells and liver tumors.

The Ganoderma lucidum material used in the experiment is the fruiting body of Ganoderma lucidum provided by Fujian Xianzhilou Biological Science and Technology Co., Ltd. The extract obtained from the Ganoderma lucidum fruiting body is referred to as GLE. 1 gram of GLE is equivalent to 93 grams of the crude drug, in which The content of Ganoderma Triterpene was 56.7%.

The animal experiment was conducted as follows:

Inoculate the liver cancer cell line (H22) into the mice subcutaneously, and then give the low, medium and high doses of GLE by intragastric administration the next day - 125 mg/kg, 250 mg/kg and 500mg/kg per day.

At the same time, there is a negative control group without treatment and a positive control group given the chemotherapy drug cyclophosphamide (once every 3 days, 30 mg/kg per gavage) to compare with the previous three groups.

There are 10 mice in each of these 5 groups of liver cancer. After 7 days of treatment, the tumor weight of the GLE low, medium and high dose groups were reduced by 30.1%, 41.7% and 59.3% in comparison with the untreated negative control group. Among them, the effect of high-dose GLE is close to the 66.1% tumor suppression rate of chemotherapeutic drugs (see table below).

The above experimental results suggest at least two things:

First, GLE can indeed inhibit tumor growth after being digested in the gastrointestinal tract.

Secondly, the inhibitory effect of GLE on the tumor was proportional to the dosage of GLE.

Why can the GLE rich in triterpenes exert anti-hepatoma effect in the body? Is it related to Ganoderma triterpenes inhibiting cancer cell proliferation? Or are other ingredients in GLE enhancing the immune system's ability to fight cancer? The real reason remains to be further studied and analyzed by scientists.

However, this experiment at least informs us that the extract from Ganoderma lucidum fruiting body is very helpful to inhibit the growth of liver cancer, and the content of Ganoderma triterpenes in this extract and the dose taken each time should be the key factors affecting the effect.

Malignant tumors are life-threatening because cancer cells can paralyze the normal operation of tissues and organs; if the growth of tumors can be limited to the extent that tissues and organs can still maintain the body's metabolism, the patients have a great chance to coexist with cancer.

Of course, the premise is to strike a balance between effectively suppressing tumors and not harming normal cells as much as possible. Otherwise, if the normal cells are exhausted, it is meaningless to clean the cancer cells.

[Reference]

Li Peng, Wei Xiaoxia, Xu Jianhua. Experimental study on anti-tumor effects of Ganoderma lucidum extract. China Modern Applied Pharmacy, 2011, 28 (9): 798-792.

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